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Access to path is denied

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Everytime I turn my computer on I get the following message in the subject line and nothing wants to work until I get rid of the message on my desk top. Anyone know what's going on and how to fix it?     

     Access to the path "C"\Windows\System32\config\systemprofile\AppData\Local\HP\Digital Imaging\hp1_skindefV2dat." is denied

 


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